Hepatic Impairment Domperidone is contraindicated in moderate or severe hepatic impairment see section 4. Dose modification in mild hepatic impairment is however not needed see section 5. Renal Impairment Since the elimination half-life of domperidone is prolonged in severe renal impairment, on repeated administration, the dosing frequency of Domperidone tablets should be reduced to once or twice daily depending on the severity of the impairment, and the dose may need to be reduced. Such patients on prolonged therapy should be reviewed regularly see sections 4.

Use in infants Neurological side effects are rare see "Undesirable effects" section. Since metabolic functions and the blood-brain barrier are not fully developed in the first months of life the risk of neurological side effects is higher in young children.

Overdosing may cause extrapyramidal symptoms in children, but other causes should be taken into consideration. Renal Impairment The elimination half-life of domperidone is prolonged in severe renal impairment. For repeated administration, the dosing frequency of domperidone should be reduced to once or twice daily depending on the severity of the impairment.

The dose may also need to be reduced. Cardiovascular effects Domperidone has been associated with prolongation of the QT interval on the electrocardiogram. During post-marketing surveillance, there have been very rare cases of QT prolongation and torsades de pointes in patients taking domperidone. These reports included patients with confounding risk factors, electrolyte abnormalities and concomitant treatment which may have been contributing factors see section 4.

Epidemiological studies showed that domperidone was associated with an increased risk of serious ventricular arrhythmias or sudden cardiac death see section 4. A higher risk was observed in patients older than 60 years, patients taking daily doses greater than 30 mg, and patients concurrently taking QT-prolonging drugs or CYP3A4 inhibitors.

Domperidone should be used at the lowest effective dose in adults and children. Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them.

The table below contains some of the most common ones associated with domperidone. You will find a full list in the manufacturer's information leaflet supplied with your medicine.

Speak with your doctor or pharmacist if any of the following become troublesome. Domperidone side-effects What can I do if I experience this? Dry mouth Try chewing sugar-free gum or sucking sugar-free sweets Fainting, a feeling of fast heartbeats palpitations Speak with a doctor straightaway Feeling anxious, feeling sleepy or weak, headaches, diarrhoea If troublesome, speak with a doctor or pharmacist for advice Breast swelling or tenderness, menstrual changes, unusual production of breast milk, itchy skin rash Let your doctor know about any of these If you experience any other symptoms which you think may be due to the medicine, speak with your doctor or pharmacist for further advice.

How to store domperidone Keep all medicines out of the reach and sight of children. Store in a cool, dry place, away from direct heat and light. Important information about all medicines Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital.

Take the container with you, even if it is empty. If you buy any medicines, check with a pharmacist that they are suitable to take with your other medicines. If you are due to have an operation or dental treatment, tell the person carrying out the treatment which medicines you are taking. This medicine is for you. Never give it to other people even if their condition appears to be the same as yours. It should only be used if the medicine is considered essential by your doctor.

This medicine passes into breast milk in very small amounts that are not expected to be harmful to a nursing infant. However, the medicine is not recommended for use in women who are breastfeeding unless the potential benefit to the mother outweighs any risks to the nursing infant.

Side effects Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine.

Just because a side effect is stated here does not mean that all people using this medicine will experience that or any side effect. Rare affect between 1 in and 1 in 10, people Increased level of prolactin milk producing hormone in the blood hyperprolactinaemia.

Sometimes this can lead to symptoms such as abnormal enlargement of breasts in men gynaecomastia , abnormal production of breast milk in men and women, or stopping of menstrual periods in women. Decreased sex drive in men. Very rare affect less than 1 in 10, people Stomach cramps. Itchy nettle-type rash urticaria. Abnormal or uncontrolled movements of the hands, legs, face, eyes, neck or tongue, for example tremor, twitching or stiffness extrapyramidal effects.

Consult a doctor straight away if you notice any symptoms like this. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Packaging Your order will be packed safely and secure and dispatched within 24 hours.

DOMPERIDONE 10 MG TABLETS

It should only be used if the medicine is considered essential by your doctor. Patients should try to take each dose at scheduled time. Consult a doctor straight away if you notice any symptoms like this. Patients on prolonged therapy should be reviewed regularly. The dose should not be doubled to tablet up for a missed dose, domperidone tablets ip 10mg. With the combination of oral domperidone 10mg four times daily and ketoconazole mg twice daily, a mean QTc prolongation of 9. This formulation is not suited for children under the age of 5 years, domperidone tablets ip 10mg, but for this group of patients the suspension is available. This domperidone passes into breast milk. This medication should not be used during pregnancy unless the benefits outweigh the risks.

ratio-Domperidone

If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital, domperidone tablets ip 10mg. Dry mouth Try chewing sugar-free gum or sucking sugar-free sweets Fainting, a feeling of fast heartbeats palpitations Speak with a doctor straightaway 10mg anxious, feeling sleepy or weak, headaches, diarrhoea If troublesome, speak with a doctor or pharmacist for advice Breast swelling or tenderness, menstrual changes, unusual production of breast milk, itchy skin rash Let your doctor know about any of these If you experience any other symptoms which you think may be due to the medicine, speak with your doctor or pharmacist for further advice. Some medical conditions may interact with Motilium. Domperidone should be used during breast feeding only if your physician considers this clearly necessary. If you are a breast-feeding mother and are taking domperidone, it may affect your baby. This medication should not be used during pregnancy unless the benefits outweigh the risks. Domperidone works by helping to move the food in your stomach through your digestive system more quickly. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine. If any of the side effects get serious, or if you domperidone any side effects not listed in the leaflet, please tell your doctor or pharmacist. You will only be recommended an anti-emetic like domperidone if the cause of your sickness is known. Other details Food timings: Patient should be advised to promptly tablet any cardiac symptoms. Sometimes this can lead to symptoms such as abnormal enlargement of breasts in men gynaecomastiaabnormal production of breast milk in men and women, or stopping of menstrual periods in women. Do not take more than three doses in any hour period. Domperidone Tablets with food, drink and alcohol It is recommended to take domperidone tablets before meals, as when taken after meals the absorption of the medicine is slightly delayed Pregnancy, breast-feeding and fertility:

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