Tab trental 400mg
On a weight basis, these doses are 24 and 11 times the maximum recommended human daily dose MRHD ; on a body-surface-area basis, they are 4. No evidence of fetal malformation was observed. There are no adequate and well controlled studies in pregnant women. Trental pentoxifylline should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Nursing Mothers Pentoxifylline and its metabolites are excreted in human milk. Because of the potential for tumorigenicity shown for pentoxifylline in rats, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
Pediatric Use Safety and effectiveness in pediatric patients have not been established. Geriatric Use Clinical studies of Trental did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects.
Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy. The active metabolite is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function.
Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function. Adverse Reactions Clinical trials were conducted using either extended-release Trental tablets for up to 60 weeks or immediate-release Trental capsules for up to 24 weeks.
Dosage ranges in the tablet studies were mg bid to tid and in the capsule studies, — mg tid. Pentoxifylline can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using pentoxifylline. How should I take pentoxifylline Trental? Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Pentoxifylline is usually taken 3 times each day, with meals. Follow your doctor's instructions.
Do not crush, chew, or break an extended-release tablet. Breaking the pill may cause too much of the drug to be released at one time. What Trental is and what it is used for 2. Before you take Trental 3. How to take Trental 4. Possible side effects 5. How to store Trental 6. What Trental is and what it is used for Trental contains a medicine called pentoxifylline. This belongs to a group of medicines called peripheral vasodilators.
It works by increasing the blood flow to the arms and legs. Trental can be used to treat: Before you take Trental Do not take Trental if: If you are not sure, talk to your doctor or pharmacist before taking Trental. Take special care with Trental Check with your doctor or pharmacist before taking your medicine if: Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines.
It may take up to 4 weeks before your symptoms improve. Keep using the medicine as directed and tell your doctor if your symptoms do not improve after 8 weeks of treatment. Store at room temperature away from moisture, heat, and light.
Seek emergency medical attention or call the Poison Help line at Overdose symptoms may include severe drowsiness, agitation, fever, flushing warmth, redness, or tingly feeling , fainting, or seizure. Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Copyright Cerner Multum, Inc.
Pentoxifylline
Special Populations Pregnant Women Reproduction studies have been performed in rats, tab trental 400mg, mice and rabbits at doses up 23, 2 and 11 times the maximum recommended daily human dose and have revealed no evidence of impaired fertility or harm to the fetus due to pentoxifylline. Careful monitoring is required. Patients on warfarin should have more frequent monitoring of prothrombin time, tab trental 400mg, trental patients with other risk factors complicated by hemorrhage e. Like all medicines, Trental can cause side tab, although not everybody gets them. Copyright Cerner Multum, Inc. Keep using the medicine as directed and tell your doctor if your trentals do not improve after 8 tab of treatment. You should not breast-feed while you are using pentoxifylline. Studies with the capsule include domestic experience, whereas studies with the extended-release tablets were conducted outside the U. Patients with hepatic impairment should be closely monitored during Trental therapy and may require lower doses. Pentoxifylline was devoid of mutagenic activity in various strains of Salmonella Ames test and in cultured mammalian cells unscheduled DNA synthesis test when tested in the presence and 400mg of metabolic activation. Such patients should be closely monitored for signs of toxicity and have their theophylline dosage adjusted as necessary. In rabbits, cats and dogs the respiration 400mg slightly stimulated. It is not known whether pentoxifylline will harm an unborn baby. Leukocyte properties of hemorrheologic importance have been modified in animal and in vitro human studies, tab trental 400mg. It undergoes a first-pass effect and the various metabolites appear in plasma very soon after dosing.
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