Cytoxan 25mg tablets - Cyclophosphamide Tablets (cyclophosphamide) dose, indications, adverse effects, interactions from karperhoeve.be
In children whose disease fails to respond adequately to appropriate adrenocorticosteroid therapy or in whom the adrenocorticosteroid therapy produces or threatens to produce intolerable side effects, cyclophosphamide may induce a remission. Cyclophosphamide is not indicated for the nephrotic syndrome in adults or for any other renal disease. Most frequently, they have been urinary bladder, myeloproliferative, or lymphoproliferative malignancies.
Second malignancies most frequently were detected in patients treated for primary myeloproliferative or lymphoproliferative malignancies or nonmalignant disease in which immune processes are believed to be involved pathologically. In some cases, cytoxan second malignancy developed several years after cyclophosphamide treatment had been discontinued, cytoxan 25mg tablets.
In a single breast cancer trial utilizing two to four times the standard dose of cyclophosphamide in conjunction with doxorubicin a small number of cases of secondary acute myeloid leukemia occurred within two years of treatment initiation.
Urinary bladder malignancies generally have occurred in patients who previously had hemorrhagic cystitis. In patients treated with cyclophosphamide-containing regimens for a variety of solid tumors, isolated case reports of secondary malignancies have been published.
One case of 25mg of the renal pelvis was reported in a patient receiving long-term cyclophosphamide tablet for cerebral vasculitis, cytoxan 25mg tablets.
The possibility of cyclophosphamide-induced malignancy should be considered in any benefit-to-risk assessment for use of the drug. Cyclophosphamide can cause fetal harm when administered to a pregnant woman and such abnormalities have been reported following cyclophosphamide therapy in pregnant women. Abnormalities were found in 25mg infants and a six-month-old fetus born to cytoxan treated with cyclophosphamide.
Ectrodactylia was found in two of the three cases. Normal tablets have also been born to women treated with cyclophosphamide during pregnancy, including the first trimester.
If this drug is used during pregnancy, or if the patient becomes pregnant while taking receiving this drug, cytoxan 25mg tablets, the patient should be apprised of the potential hazard cytoxan the fetus. Women of childbearing potential should be advised to avoid becoming pregnant, cytoxan 25mg tablets. Cyclophosphamide interferes with oogenesis and spermatogenesis. It may cause sterility in both sexes. Development of sterility appears to depend on the dose of cyclophosphamide, duration 25mg tablet, and the state of gonadal function at the time of treatment.
Cyclophosphamide-induced sterility may be irreversible in some patients. Amenorrhea associated with decreased estrogen and increased gonadotropin secretion develops in a significant proportion of women treated with cyclophosphamide.
Cyclophosphamide
Affected patients generally resume regular menses within a few months after cessation of therapy. Girls treated with cyclophosphamide during prepubescence generally develop secondary sexual characteristics normally and have regular tablets.
Ovarian fibrosis with apparently complete loss 25mg germ cells cytoxan prolonged cyclophosphamide treatment in late prepubescence has been reported. Girls treated with cyclophosphamide during prepubescence subsequently have conceived, cytoxan 25mg tablets. Men treated with cyclophosphamide may develop oligospermia or azoospermia associated with increased gonadotropin but normal testosterone secretion, cytoxan 25mg tablets.
Sexual potency and libido are unimpaired in these patients. Boys treated with cyclophosphamide during prepubescence develop secondary sexual characteristics normally, but may have oligospermia or azoospermia and increased gonadotropin secretion.
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Some degree of testicular 25mg may occur. Cyclophosphamide-induced azoospermia is reversible in some patients, though the reversibility may not occur for several years after cessation of therapy. Men temporarily rendered sterile by cyclophosphamide have subsequently fathered normal children, cytoxan 25mg tablets.
Urinary System Hemorrhagic cystitis may develop in tablets treated with cyclophosphamide. Rarely, this condition can be severe and even fatal. Fibrosis of the urinary bladder, sometimes extensive, also may develop with or without accompanying cystitis. Atypical urinary bladder epithelial cells may appear in the urine. These adverse effects appear to depend on the dose of cyclophosphamide and the duration of therapy. Such bladder injury is thought to be due to cyclophosphamide metabolites excreted in the urine.
Forced fluid intake helps to assure an ample output of urine, necessitates frequent voiding, cytoxan 25mg tablets, and cytoxan the time the drug remains in the bladder. This helps to prevent cystitis.
What is Cytoxan?
Hematuria usually resolves in a few days after cyclophosphamide treatment is stopped, but it may persist, cytoxan 25mg tablets. It is usually necessary to discontinue cyclophosphamide therapy in cymbalta 75mg of severe hemorrhagic cystitis. Cardiac Toxicity Although a few instances of cardiac dysfunction have been reported following use of recommended doses of cyclophosphamide, no causal relationship has been established.
Acute cytoxan toxicity has been reported with doses as low as 2. In a few instances with high doses cytoxan cyclophosphamide, severe, and sometimes fatal, congestive heart failure has occurred after the first cyclophosphamide dose.
Histopathologic examination has primarily shown hemorrhagic myocarditis. Hemopericardium has occurred secondary to hemorrhagic myocarditis and myocardial necrosis. Pericarditis has been reported independent of any hemopericardium. No residual cardiac abnormalities, as evidenced by electrocardiogram or echocardiogram appear to be present in patients surviving episodes of apparent cardiac toxicity associated with high doses of cyclophosphamide. Cyclophosphamide has been reported to potentiate doxorubicin-induced cardiotoxicity.
Infections Treatment with cyclophosphamide may cause significant cytoxan of immune responses. Serious, sometimes fatal, infections may develop in severely immunosuppressed patients. Cyclophosphamide tablet may not be indicated, or should be interrupted, or the tablet reduced, cytoxan 25mg tablets, in patients cytoxan have or who develop viral, bacterial, fungal, protozoan, or helminthic infections. Other Anaphylactic reactions have been reported; death has also been reported in association with this event.
Possible cross-sensitivity with tablet alkylating agents has been reported. Urine should also be examined regularly for red cells which may precede hemorrhagic cystitis.
Drug Interactions The rate of metabolism and the leukopenic activity of cyclophosphamide reportedly 25mg increased by chronic administration of high doses of phenobarbital. The physician should be alert for possible combined drug actions, cytoxan 25mg tablets, desirable or undesirable, involving cyclophosphamide even though cyclophosphamide has been used successfully concurrently with other drugs, including other cytotoxic drugs.
Cyclophosphamide treatment, cytoxan 25mg tablets, which tablets a marked and cytoxan inhibition of cholinesterase activity, potentiates the effect of succinylcholine chloride. If 25mg patient has been 25mg with cyclophosphamide within 10 days of general anesthesia, the anesthesiologist should be alerted.
Adrenalectomy Since cyclophosphamide has been reported to be more tablet 25mg adrenalectomized dogs, adjustment of the doses of both replacement steroids and cyclophosphamide 25mg be necessary for the adrenalectomized patient. Wound Healing Cyclophosphamide may interfere with normal wound healing.
Carcinogenesis, Mutagenesis, and Impairment of Fertility.
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