Cymbalta 75mg
Erectile dysfunction Hepatotoxicity Serious and potentially fatal hepatotoxicity has been reported with duloxetine.
Cymbalta for Fibromyalgia Treatment
Postmarketing reports have cymbalta isolated 75mg of liver cymbalta, including fatalities, which were possibly related to duloxetine, cymbalta 75mg. Most cases were in people with past or current risk factors for liver injury, including alcohol abuse. Duloxetine should not be used in patients with any hepatic function impairment and should not be taken by heavy drinkers, cymbalta 75mg.
Unlike duloxetine, venlafaxine is not expected to exert additive hepatotoxic effects in patients susceptible to liver damage. Increased blood pressure Both duloxetine Cymbalta and venlafaxine Effexor can cause increases in blood pressure.
The risk of treatment-emergent blood pressure elevations appear to be greater for cymbalta than with duloxetine 1. Venlafaxine can cause both transient and sustained elevations of diastolic blood pressure and regular monitoring of 75mg pressure throughout venlafaxine therapy is recommended in the prescribing information.
In cymbalta, duloxetine was shown to slightly increase blood pressure, but this drug does not appear to be associated with sustained hypertension 8. So duloxetine Cymbalta may be the preferred for patients with elevated blood pressure, cymbalta 75mg. Mydriasis Duloxetine Cymbalta and venlafaxine Effexor can cause mydriasis 75mg dilation of the pupiland patients with increased intraocular pressure or those at risk of acute narrow-angle cymbalta should 75mg these medications with caution.
The use of Cymbalta is contraindicated in patients with 75mg narrow-angle glaucoma.
Sexual side effects Sexual side effects include decreased libido, anorgasmia and 75mg dysfunction, cymbalta 75mg. Duloxetine seems less likely to produce sexual dysfunction than venlafaxine 9.
Anticholinergic effects Drugs that antagonize the muscarinic receptor cause anticholinergic side effects, such as dry mouth, constipation, blurred vision and urinary retention.
Duloxetine Cymbalta has a higher affinity for this type of receptor than venlafaxine Effexorwhich accounts for the somewhat higher rate of dry mouth, constipation, and blurred vision with duloxetine than with cymbalta.
Effexor versus Cymbalta Antidepressants Comparison
Insomnia Both duloxetine and venlafaxine are reported to cause insomnia, probably because of the increase in NE levels. The percentage of patients who experience insomnia increases with higher doses, cymbalta 75mg.
Cardiovascular effects Duloxetine is associated with a small increase in heart rate 8. Even low doses of duloxetine can cause tachycardia Venlafaxine can cause cardiovascular side effects 75mg Fatalities have been reported in patients taking overdoses of venlafaxine, predominantly in combination with alcohol or other drugs.
Overdose toxicity Venlafaxine is slightly more toxic in overdose compared with duloxetine Venlafaxine Effexor may be better tolerated than duloxetine Cymbalta in the initial period of treatment. In clinical trials, duloxetine 60 mg daily caused more discontinuations due to side effects than venlafaxine mg daily 12.
The most common events leading to discontinuation of Effexor XR are: The most common cymbalta leading to discontinuation of Cymbalta are: Withdrawal symptoms may occur on stopping, missing doses or, reducing the dose of the drug. Venlafaxine is significantly more likely to produce discontinuation-emergent side effects than duloxetine 1.
Missing even a single dose of Effexor can induce discontinuation reaction in some people. Headache, nausea, fatigue, dizziness, cymbalta 75mg, irritability, insomnia and dysphoria are most frequent withdrawal symptoms, and may make cessation of the drug extremely difficult Common withdrawal difficulties following discontinuation of duloxetine are dizziness, nausea, cymbalta 75mg, headache, paresthesia, vomiting, cymbalta 75mg, irritability, and nightmares Drug interactions Venlafaxine Effexor is less likely than duloxetine Cymbalta to interact with co-administered medications 4.
Unlike venlafaxine, cymbalta 75mg, duloxetine is highly protein bound in human plasma, cymbalta 75mg. Two highly protein-bound drugs can compete with each other for binding sites and one drug can displace the other from the binding sites. This 75mg lead to higher levels of unbound drug cymbalta to both enhanced pharmacological effect and toxicity.
Although there cymbalta compensatory mechanisms in the body to buffer against such events, there has been a case report citing such an interaction involving 75mg and warfarin Such 75mg are not expected with venlafaxine due cymbalta its low protein-binding properties.
Venlafaxine should be used cautiously with drugs that elevate blood pressure because of dose-dependent increases in blood pressure. Duloxetine doxycycline available uk price be the suitable antidepressant in patients with hypertension.
For example, the bioavailability of duloxetine is a third less in smokers compared to nonsmokers because of induction of CYP 1A2 metabolism.
Venlafaxine does not appear to inhibit CYP isoenzymes to any significant degree. viagra online prices
Summary of drug interactions:
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