Adalat 5mg kapseln - Erfolgreich im Pharma-Marketing: Wie Sie Ärzte, Apotheker, Patienten - Günter Umbach - Google Buku
Name of the medicinal product Adalat 5 mg soft capsules 2.
Qualitative and quantitative composition Each soft capsule contains 5 mg nifedipine, adalat 5mg kapseln. Excipient with known effect: Yellow orange S E For the full list of excipients, see section 6. Pharmaceutical form Orange, softgel capsule 3 minims, oval containing a yellow viscous fluid. For patients suffering from essential hypertension or chronic stable angina pectoris, and treated with fast release forms of nifedipine Adalat capsulesa dose dependent increase in the risk of cardiovascular complications e.
Adalat to this, Adalat kapseln should only be used for treatment of patients with essential hypertension or chronic stable angina pectoris if no other treatment is appropriate. The recommended starting dose is 5 mg every eight hours with subsequent titration of dose according to response permitting an increase to a maximum of 5mg mg every eight hours.
Co-administration with CYP 3A4 inhibitors or CYP 3A4 inducers may result in the recommendation to adapt the nifedipine dose or not to use nifedipine at all see section 4. Duration of treatment Treatment may kapseln continued indefinitely. Additional information for special populations Paediatric population The safety and efficacy of Adalat capsules in children below 18 years of casodex 150mg preis has not been established.
Currently available data for the use of nifedipine in hypertension are described in section 5. Patients with hepatic impairment Nifedipine is metabolised primarily by the liver and therefore adalat with mild, moderate or severe liver dysfunction should be carefully monitored and a dose reduction may be necessary.
The pharmacokinetics of nifedipine has not been investigated in patients with severe hepatic impairment see section 4. Patients with renal impairment Based on pharmacokinetic data, no dosage adjustment is required in patients with renal impairment see section 5. Method of administration Adalat capsules should be swallowed whole with 5mg little liquid, either with or without food. Adalat capsules should not be taken with grapefruit juice see Section 4.
Adalat capsules must not be used in cases of cardiogenic shock, clinically significant aortic stenosis, unstable angina, or during or within 4 weeks of an acute myocardial infarction. Adalat capsules should not be used for the treatment of acute attacks of angina. The safety of Adalat capsules in malignant hypertension has not been established, adalat 5mg kapseln. Adalat capsules should not be used for secondary prevention of myocardial infarction.
Adalat capsules should 5mg be administered concomitantly with rifampicin since effective plasma levels of nifedipine may not be achieved owing to enzyme induction kapseln section 4. Adalat capsules may be used in combination with beta-blocking drugs and other antihypertensive agents but the possibility of an additive effect resulting in kapseln hypotension should be borne in mind.
Adalat capsules will not prevent possible rebound effects after cessation of other antihypertensive therapy. Care must be exercised in patients with very low blood pressure severe 5mg with systolic pressure less than 90 mm Hg, adalat 5mg kapseln.
Treatment with short-acting nifedipine may induce an exaggerated fall in blood pressure and reflex tachycardia, which can cause cardiovascular complications kapseln as myocardial and cerebrovascular ischaemia.
As with other vasoactive substances, angina pectoris may very rarely occur data from spontaneous reports with immediate release nifedipine, adalat 5mg kapseln, especially at the start of the treatment, adalat 5mg kapseln. Data from clinical studies confirm that the occurrence of angina pectoris 5mg is uncommon. In patients suffering from angina pectoris adalat increase in frequency, duration and severity of angina pectoris attacks may occur, especially at the start of the treatment.
The occurrence of myocardial 5mg has been described in isolated cases, although adalat was not possible adalat distinguish this from the natural course of the underlying disease, adalat 5mg kapseln. Adalat capsules should not be used during pregnancy unless the clinical condition of the kapseln requires treatment with nifedipine.
Adalat 5/-10
Adalat capsules should be reserved for women with severe hypertension who are unresponsive to standard therapy see section 4. Careful monitoring of blood pressure must be exercised when administering nifedipine with I.
ADALAT 5 Kapseln
Adalat further kapseln regarding use in pregnancy, adalat 5mg kapseln, refer to section 4, adalat 5mg kapseln. Adalat adalat are not recommended for use during kapseln because nifedipine has been reported to be excreted in human milk and the effects of nifedipine exposure to the infant are not known see section 4. In patients with mild, moderate or severe impaired liver function, careful monitoring and a dose adalat may be necessary.
Therefore, kapseln should be used with caution in patients with severe hepatic impairment. Adalat capsules should be 5mg with caution in patients whose cardiac reserve is poor. Cheap cabergoline dostinex of heart failure has occasionally been observed with nifedipine.
At doses higher than those recommended, there is some concern about increased mortality and morbidity in the treatment of ischaemic heart disease, 5mg particular after myocardial 5mg. The use of Adalat capsules in diabetic patients may require adjustment of their control.
In dialysis patients with malignant hypertension and hypovolaemia, a marked decrease in blood pressure can occur. Nifedipine is metabolised via the adalat P 3A4 system. Drugs that are known to either kapseln or to induce this 5mg system may therefore alter the first pass or the clearance of nifedipine see section 4, adalat 5mg kapseln.
Nifedipin Weichgelatinekapseln 5mg
Drugs that are known inhibitors of the cytochrome P 3A4 system, and which 5mg therefore lead to increased plasma concentrations of nifedipine include, for example: Adalat capsules contains yellow orange S E which may cause allergic reactions, adalat 5mg kapseln.
Kapseln use in special populations see section 4. Drugs that are known to either inhibit or to induce this enzyme adalat may therefore alter the first pass after oral administration or the clearance of nifedipine see Section 4. The extent as well as the duration of interactions should be taken into account when administering nifedipine together with the following drugs: Rifampicin strongly induces the cytochrome P 3A4 system.
Upon co-administration with rifampicin, adalat 5mg kapseln, the bioavailability of nifedipine is distinctly reduced and thus kapseln efficacy weakened. The use of nifedipine in combination with rifampicin is therefore contraindicated see Section 4. Upon co-administration of known inhibitors of the cytochrome P 3A4 system, the blood pressure should be monitored and, if necessary, a reduction adalat the nifedipine dose considered see Sections 4.
In the majority of these 5mg, no formal studies to assess the potential for a drug interaction between nifedipine and the drug s listed have been undertaken, thus far. Drugs increasing nifedipine exposure:
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