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In a study of healthy male volunteers, co-administration of sildenafil at steady state 80 mg t. Concomitant administration of strong CYP3A4 inducers, such as rifampin, is expected to cause greater decreases in plasma levels of sildenafil.
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In healthy male volunteers, there was no evidence of a clinically significant effect of azithromycin mg daily for 3 days on the systemic exposure of sildenafil or viagra major circulating metabolite. Pharmacokinetic data from patients in clinical trials showed no effect on sildenafil pharmacokinetics of CYP2C9 inhibitors such as tolbutamide, warfarinCYP2D6 inhibitors such as selective serotonin 25mg inhibitors, tricyclic antidepressantsthiazide and related diuretics, ACE inhibitors, and calcium channel blockers.
These effects on the metabolite are not expected to be of clinical price. In Vivo Studies No significant interactions were shown with tolbutamide mg or warfarin 40 mgboth of which are metabolized by CYP2C9. In a study of healthy male volunteers, viagra 25mg price, sildenafil mg did not affect the steady state pharmacokinetics of the HIV protease inhibitors, viagra 25mg price, saquinavir and ritonavir, both of which are CYP3A4 substrates.
Sildenafil at steady state, at a dose not approved for the treatment of erectile dysfunction 80 mg t.
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