For the prevention of PONV: Zofran can be administered orally or by intravenous or intramuscular injection. For the treatment of established PONV: Intravenous or intramuscular administration is recommended. No studies have been conducted on the use of orally administered ondansetron in the prevention or treatment of post-operative nausea and vomiting; slow IV injection not less than 30 seconds is recommended for this purpose. For prevention of PONV in paediatric patients having surgery performed under general anaesthesia, a single dose of ondansetron may be administered by slow intravenous injection not less than 30 seconds at a dose of 0.
For the treatment of PONV after surgery in paediatric patients having surgery performed under general anaesthesia, ondansetron odt 4mg tablets, a single dose of Zofran may be administered by slow intravenous injection not less than 30 seconds at a dose of 0.
There is limited experience in the use of Zofran in the prevention and treatment of ondansetron nausea and vomiting in the elderly, however Zofran is well tolerated in patients over 65 years receiving chemotherapy.
Patients with Renal impairment: Patients with Hepatic impairment: Clearance of Zofran is significantly reduced and serum half life significantly prolonged in subjects with 4mg or severe impairment of hepatic function.
Respiratory events should be treated symptomatically and tablets should pay particular attention to them as precursors of hypersensitivity reactions. Ondansetron prolongs the QT interval in a dose-dependent manner see section 5.
In addition, post- marketing cases of Torsade de Pointes have been reported in patients using ondansetron. Avoid ondansetron in patients with odt long QT syndrome, ondansetron odt 4mg tablets.
Ondansetron should be administered with caution to patients who have or may develop prolongation of QTc, ondansetron odt 4mg tablets, including patients with electrolyte abnormalities, congestive heart odt, bradyarrhythmias or patients taking other medicinal products that lead to QT prolongation or electrolyte abnormalities.
Hypokalaemia and hypomagnesaemia should be corrected prior to ondansetron administration. There have been post-marketing reports describing patients with serotonin syndrome including altered mental status, autonomic instability and neuromuscular abnormalities following the concomitant use of ondansetron and other serotonergic drugs including selective serotonin reuptake inhibitors SSRI and serotonin noradrenaline reuptake inhibitors SNRIs.
If concomitant treatment with ondansetron and other serotonergic drugs is clinically warranted, appropriate observation of the patient is advised. As ondansetron is known to increase large bowel transit time, patients with signs of subacute intestinal obstruction should be monitored following administration. In patients with adenotonsillar surgery prevention of nausea and vomiting with ondansetron may mask occult bleeding. Therefore, such patients should be followed carefully tablet ondansetron.
Patients with rare hereditary problems of galactose intolerance, Lapp lactase-deficiency or glucose- galactose malabsorption should not take ondansetron medicine.
Paediatric patients receiving ondansetron with hepatotoxic chemotherapeutic agents should be monitored closely for impaired hepatic function. The comparative efficacy of these two different dosing regimens has not been investigated in clinical trials. Cross-trial comparison indicates similar efficacy for both regimens see section 5, ondansetron odt 4mg tablets.
Specific studies have shown that there are no interactions when ondansetron is administered with alcohol, temazepam, furosemide, ondansetron odt 4mg tablets, alfentanil, tramadol, morphine, lidocaine, ondansetron odt 4mg tablets, thiopental, or propofol.
Ondansetron is metabolised by multiple hepatic cytochrome P enzymes: Due to the multiplicity of metabolic enzymes odt of metabolising ondansetron, tablet inhibition or reduced activity of one enzyme e.
CYP2D6 genetic deficiency is normally compensated by other enzymes and should result in little or no 4mg change in overall ondansetron clearance or dose requirement.
In Canada - Call your tablet for medical advice about side effects, ondansetron odt 4mg tablets. You may report side effects to Health Canada at ondansetron List Ondansetron Hcl side effects by likelihood and severity. Precautions Before taking ondansetrontell your doctor or pharmacist if you are allergic to it; or to other serotonin blockers e. This product may contain inactive ingredients, which can cause allergic reactions or other problems.
Talk to your pharmacist for more details. Odt using this medicationtell your doctor or pharmacist your medical history, 4mg of: Ondansetron may cause a condition that affects the heart buy benazepril online no prescription 4mg prolongation.
The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using ondansetron, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: Low levels of potassium or magnesium in the blood may also increase your risk of QT ondansetron.
Talk to your doctor about using ondansetron safely. Odt drug may make you dizzy or drowsy. Do odt drive, use machinery, or do any activity that requires alertness until you are sure you can perform such ondansetron safely, ondansetron odt 4mg tablets. To minimize dizziness and lightheadednessget up slowly when rising 4mg a sitting or lying position. Older adults may be more sensitive to the side effects of this drug, especially QT ondansetron see above.
4mg medication should be used only tablet clearly needed during pregnancy. Discuss the risks and benefits with your tablet.
It is not known tablet this drug passes into ondansetron milk. Consult your doctor before breast -feeding. What should I know 4mg pregnancy, tablet and administering Ondansetron Hcl to children or the elderly?
Interactions Your healthcare professionals e. Do not start, stop or change odt dosage of any medicine before checking with them first. This drug should not be used with the following medication because a very serious interaction ondansetron occur: If you are currently using the medication listed above, 4mg your doctor odt pharmacist before starting ondansetron, ondansetron odt 4mg tablets.
Before using this medication, tell your doctor of all nonprescription and prescription medication you may use, especially of: Ask your doctor or pharmacist for more details. Many drugs besides ondansetron may affect the heart rhythm QT prolongationincluding dofetilidepimozideprocainamideondansetron odt 4mg tablets, amiodaronequinidinesotalolmacrolide antibiotics such as erythromycinamong others.
Therefore, before using ondansetron, report all medications you are currently using to your doctor or pharmacist.
This document tramadol inyectable precio not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use.
Keep a list of all your medications with you, and share the list with your doctor and pharmacist.
ondansetron Does Ondansetron Odt interact tablet other medications? Overdose 4mg someone has overdosed and has serious symptoms such as passing out or trouble breathingcall Otherwise, call a poison control center right away.
US residents can call their local poison control center at Canada residents can call a provincial poison control center. Notes Do not share this product with others.
Consult your doctor for more details. Missed Dose Try to take each dose at the scheduled time. If you miss a dose, take it as soon as remembered unless it is near the time for the next dose. In that case, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
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