However, no overall 2mg were observed in safety between older and younger patients on tolterodine in the Phase 3, week, controlled clinical studies; therefore, no tolterodine dosage adjustment for elderly patients detrol recommended.
Renal Impairment Renal impairment can significantly alter the disposition of tolterodine immediate release and its metabolites.
Exposure levels of other metabolites of detrol e. The recommended 2mg for patients with severe renal impairment CCr: Hepatic Impairment Liver impairment can significantly alter the disposition of tolterodine immediate release.
In a study of tolterodine immediate release conducted in cirrhotic patients Child-Pugh Class A and Bdetrol la 2mg, the elimination half-life of tolterodine immediate release was longer in cirrhotic patients mean, 7.
The clearance of orally administered tolterodine immediate release was substantially lower in cirrhotic patients 1. Gender The pharmacokinetics of tolterodine immediate release and 5-HMT are not influenced by gender, detrol la 2mg. Mean Cmax of tolterodine immediate release 1.
Mean AUC values of tolterodine 6. The elimination half-life of tolterodine immediate release for both males and females is 2.
Race Pharmacokinetic differences due to race have not been established. Overdosage Overdosage with Detrol LA Capsules can potentially result detrol severe central anticholinergic 2mg and should be treated accordingly.
ECG monitoring is recommended in the event of overdosage. A month-old child who ingested 5 to 7 tolterodine immediate release 2 mg tablets was treated with a suspension of activated charcoal and was hospitalized overnight with symptoms of dry mouth.
The child fully recovered. The active moiety, detrol la 2mg, tolterodine, is a muscarinic receptor antagonist.
The chemical name of tolterodine tartrate is R -N,N-diisopropyl 2-hydroxymethylphenyl phenylpropanamine L-hydrogen tartrate. The empirical formula of tolterodine tartrate 2mg C26H37NO7. Tolterodine tartrate is a white, crystalline powder with a molecular weight of 2mg a study to assess the effect of detrol on the pharmacokinetics of tolterodine immediate release and its metabolites, detrol la 2mg, it detrol observed that fluoxetine significantly inhibited the metabolism of tolterodine immediate release in extensive metabolizers, resulting in a 4.
Fluoxetine 2mg alters the pharmacokinetics in patients who would otherwise be extensive metabolizers of tolterodine immediate release to resemble the pharmacokinetic profile in poor metabolizers. Other Drugs Metabolized By Cytochrome P Isoenzymes Tolterodine immediate release does not cause clinically significant interactions with other drugs metabolized by the major drug metabolizing CYP enzymes.
In vivo drug-interaction data show that tolterodine immediate release does not result in clinically relevant inhibition of CYP1A2, 2D6, 2C9, 2C19, or 3A4 as evidenced by lack of influence 2mg the marker drugs caffeine, debrisoquine, detrol la 2mg, S-warfarin, and omeprazole. In vitro data show that tolterodine immediate release is detrol competitive inhibitor of CYP2D6 detrol high concentrations Ki 1, detrol la 2mg.
CYP3A4 Inhibitors 2mg effect of mg daily dose of ketoconazole on the pharmacokinetics of tolterodine immediate release was studied in 8 healthy volunteers, all of whom detrol poor metabolizers see Pharmacokinetics, Variability in Metabolism for discussion detrol poor metabolizers.
In the presence of ketoconazole, the mean Cmax and AUC of tolterodine increased by 2 and 2, detrol la 2mg. 2mg
Based on these findings, detrol la 2mg, other potent CYP3A inhibitors such as other azole antifungals e. Warfarin In healthy volunteers, coadministration of tolterodine immediate release 4 mg 2 mg bid for 7 days and a single dose of warfarin 25 mg on detrol 4 had no effect on prothrombin time, Factor VII suppression, or on the pharmacokinetics of warfarin. What are the other precautions for 2mg
Avoid exposure to sunlight while on the drug since it inhibits sweating and heatstroke may occur. What are the Drug Interactions of Tolterodine? Tolterodine should be avoided with: Anti-arrhythmic drugs like amiodarone and 2mg which are used in the treatment of arrhythmias detrol heart rhythms as it would result in increased chances of abnormal heartbeat.
Antibiotics like erythromycin and clarithromycin, detrol la 2mg, azole antifungals like itraconazole and ketoconazole, the antiviral drug ritonavir, detrol la 2mg, antidepressant fluoxetine and anticholinergics like scopolamine and atropine, since they could increase 2mg side effects of the detrol. What are the storage conditions of Tolterodine?
Store the drug in a tightly closed container at room temperature. Keep away from excess heat and moisture.
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