Biaxin xl er 500mg - Biaxin, Biaxin XL (Clarithromycin): Side Effects, Interactions, Warning, Dosage & Uses
Based on limited data in 24 patients, when Biaxin tablets were administered two to four hours prior to oral zidovudine, the steady-state zidovudine Cmax was increased by approximately 2-fold, whereas the AUC was unaffected, biaxin xl er 500mg. Simultaneous administration of BIAXIN tablets and didanosine 500mg 12 HIV-infected adult patients resulted in no statistically significant change in didanosine pharmacokinetics.
Steady-state concentrations of OH clarithromycin were not significantly affected by concomitant administration of fluconazole. Clarithromycin may be alprazolam pills online without dosage adjustment to patients with normal renal function taking ritonavir.
Biaxin XL (Clarithromycin ER)
However, for patients with renal impairment, the following dosage adjustments should be considered, biaxin xl er 500mg. Spontaneous reports in the post-marketing period suggest that concomitant administration biaxin clarithromycin and oral anticoagulants may potentiate the effects of the oral anticoagulants.
Prothrombin times should be carefully monitored while patients are receiving clarithromycin and oral anticoagulants simultaneously. Elevated digoxin serum concentrations in patients receiving clarithromycin and digoxin concomitantly have also been reported in post-marketing surveillance. Some patients have shown clinical signs consistent with digoxin toxicity, including potentially fatal arrhythmias.
Serum digoxin concentrations should be carefully monitored while patients are 500mg digoxin and clarithromycin simultaneously, biaxin xl er 500mg. Patients should be monitored for clinical symptoms of colchicine toxicity.
Erythromycin and clarithromycin are substrates and inhibitors of the 3A isoform subfamily of the cytochrome P enzyme system CYP3A. Coadministration of erythromycin or clarithromycin and a drug primarily metabolized by CYP3A may be associated with elevations 500mg drug concentrations that could increase or prolong both the therapeutic and adverse effects of the concomitant drug.
Dosage adjustments may be considered, and when possible, serum concentrations of drugs primarily metabolized by CYP3A should be monitored closely in patients concurrently receiving clarithromycin or erythromycin. The following are examples of some clinically significant CYP3A based drug interactions.
Biaxin with other drugs metabolized by the CYP3A isoform are also possible. Increased serum concentrations of carbamazepine and the active acid metabolite of terfenadine were observed in clinical trials with clarithromycin. Electrocardiograms should 500mg monitored for QTc prolongation during coadministration of clarithromycin with these drugs. Cialis 10mg n3 concentrations of these medications should also be monitored.
Triazolobenziodidiazepines Such as Triazolam and Alprazolam and Related Benzodiazepines Such as Midazolam Erythromycin has been reported to decrease the clearance of triazolam and midazolam, and thus, may increase the pharmacologic effect of these benzodiazepines, biaxin xl er 500mg.
Clarithromycin side effects Get emergency medical help if you have any of these signs of an allergic reaction to clarithromycin: Call your doctor at once if you have: Older adults may be more likely to have heart rhythm side effects, including a life-threatening fast heart rate. Clarithromycin biaxin also cause severe liver symptoms.
Stop taking clarithromycin and call your doctor at once if you have any of these liver symptoms: Common clarithromycin side effects may include: This is not a complete list of side effects and others may occur, biaxin xl er 500mg.
Biaxin XL Tablet, Extended Release 24 Hr
Call your doctor for medical advice about side effects. Side effects in more detail What other drugs will affect clarithromycin? Many drugs can interact 500mg clarithromycin. Electrocardiograms should be monitored for QT prolongation during coadministration of clarithromycin with these drugs.
Serum concentrations of these medications should also be monitored, biaxin xl er 500mg. Postmarketing reports indicate that coadministration of clarithromycin biaxin ergotamine or dihydroergotamine has been associated with acute ergot toxicity characterized by vasospasm and ischemia of the extremities and other tissues including central nervous system. Erythromycin has been reported to decrease the clearance of triazolam and midazolam, come comprare del viagra thus, may increase the pharmacologic effect of these benzodiazepines.
There have been postmarketing reports of drug interactions and CNS effects e. As with other macrolides, clarithromycin has been reported to increase concentrations of HMG-CoA reductase inhibitors e. Rare reports of rhabdomyolysis have been reported in patients taking these drugs concomitantly. Erythromycin has been reported to increase the systemic exposure AUC of sildenafil.
A similar interaction may occur with 500mg reduction of sildenafil dosage should be considered biaxin Viagra package insert. In addition, there have been reports of interactions of erythromycin 500mg clarithromycin with drugs not thought to be metabolized biaxin CYP3A, including hexobarbital, phenytoin, biaxin xl er 500mg, and valproate. The following in vitro mutagenicity tests have been conducted with clarithromycin: In addition, a Bacterial Reverse-Mutation Test Ames Test has been performed on clarithromycin metabolites with negative results.
This effect has been attributed to marked maternal toxicity of the drug at this high dose.
Long-term studies in animals have not been performed to evaluate the carcinogenic potential of clarithromycin. There are no adequate and well-controlled studies in pregnant women. It is not known whether clarithromycin is excreted 500mg human milk, biaxin xl er 500mg. Because many drugs biaxin excreted in human milk, caution should be exercised when clarithromycin is administered to a nursing woman.
It is known that clarithromycin is excreted in the milk of lactating animals and that other drugs of this class are excreted in human milk. Safety and effectiveness of clarithromycin in pediatric patients under 6 months of age have not been established.
The safety of clarithromycin has not been studied in MAC patients under the age of 20 months. Neonatal and juvenile animals tolerated clarithromycin in a manner similar to adult animals. Young animals were slightly more intolerant to acute overdosage and to subtle reductions in erythrocytes, platelets, and leukocytes but were less sensitive to toxicity in the liver, kidney, thymus, and genitalia.
This medication should not be used by people with severe liver problems. If you develop symptoms of liver problems e. This medication can worsen or cause symptoms of myasthenia gravis.
If your symptoms worsen or you develop new symptoms such as double vision, drooping eyelids, muscle weakness, or difficulty chewing or swallowing, biaxin xl er 500mg, contact your doctor. Clarithromycin should not be used during pregnancy, especially the first biaxin months of pregnancy, unless there is no 500mg alternative therapy. If you become pregnant while taking this medication, contact your doctor.
This medication passes into breast milk. If you are a breast-feeding mother and are taking clarithromycin, it may affect your baby. Do not stop taking this medication without consulting your doctor.
Do not give this medication to anyone else, even 500mg they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed biaxin. What form s does this medication come in? This medication does not contain tartrazine, biaxin xl er 500mg. How should I use this medication? When used with other medications to kill H. This total daily dose should be divided in 2 equal doses given 12 hours apart.
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