We're in a very strong position. You also need to have demand not just the price to make sure that the rebates are realized by the payer. So we're going to continue to critically asses that, we'll make decisions very thoughtful way, but you know we're certainly going to make sure patients have access to our drugs. Boris Peaker I just have a quick question on GERD drug, can you just discuss maybe opportunity for reducing the pill burden specifically, can you make it mg may then a single pill.

Mark Currie Yeah, thank Boris, this is Mark. So we are actively working as I've indicated in the script, taking in reducing the pill burden to two pill today, and so that would be to two timesthat that I think right away when we look at it is within that scope of what we think the gastric retentive formulation that we currently have without having to change any characteristic for the formulation other than the price at a pill, average wholesale price of allopurinol, so that we feel very comfortable with, I don't think we're ready to price to in one pill at this particular point in time.

But obviously we're going to continue to try to innovate and find way to all to mid make the best drug for average, but we're excited about that what we've seen three pill, today patient seem to accept that average readily, but in our view we're going to try to continue to innovate to make it even easier for him.

Boris Peaker Great, average wholesale price of allopurinol, thank you average much for taking my questions. And our next question comes from the line of David Maris from Wells Fargo. David Maris Good afternoon, a couple of questions. And can you just walk us through a little bit of your thinking on given the modest sales allopurinol to ramp and how different this is for patients?

And then I have a follow up, average wholesale price of allopurinol. Thomas Graney Sure, I'll take that. I guess that the first question with regard to the PDUFA date we never really have disclosed that officially, what we have said that wholesale be launching early in the wholesale quarter of this allopurinol, and as everything that we see right now is still allopurinol track to do that. So that looks good. We're phentermine purchase canada physicians beginning to adopt it, they're price that certainly the significant benefit as far as getting patients to go.

But you know as we said in the past, there's a lot of things we wholesale about this category highly symptomatic clear on unmet medical need, there's really been no innovation here for quite some time and this is really the clear advance, first advancement in care.

But to that end it's been a pretty stagnant market, physicians are pretty complete with how they're approaching the patients, average wholesale price of allopurinol.

But they're certainly beginning to recognize the need for more effective therapy and DUZALLO price makes a very simple solution to have one pill wholesale a day and get twice as many people to go. And we saw that average on, when we did the first allopurinol, when we decided to license the rights in and as we move forward to launch DUZALLO, average wholesale price of allopurinol, everything we're hearing from physicians very favorable.

Thank you very much. That actually answers my question. David Lebowitz Thank you very much for taking my question. The first question on IW, you're price to be releasing data at some point that stratifies the patients based on the level of bio reflux they actually have?

Mark Currie Yeah, so this is Mark, I'll take that question. Yeah, we've got a very rich obviously at that point we've got top line data, and it's a very rich dataset that we've seen with average clear drug effect. We certainly are looking at the bio asset level than a very small number of patients that we did, so at this point we don't know what that data looks like, but I would expect that across this study because of a very interesting profile we have a patient studies that either have very severe heartburn severity or they have [indiscernible] or clear demonstration of reflux and including patient that had bio reflux, we would expect that coming up meetings in GI space to be gratifying patient for across and making that definition a little more clear.

David Lebowitz Thanks for that. In addition what we also see data on the lower doses? Mark Currie Yeah, we will release the full data set for the study once we - do a quite complete characterization of to does versus the doses. David Lebowitz And I just had curiosity, how big is the milligram pill for this drug? The other part is that the pill itself actually doesn't change too much in size versus the versusso we nortem 20mg tabs temazepam expect to see hardly any change in that, it's a little, but not much of a vitamin type pill, lot of time but you would see.

Thanks for taking my questions. Eric Joseph Hey guys. It's Eric on for Anupam. First on LINZESS, I'm wondering how we should be speaking about commercial margin for the second half of the year, sort of with guidance to spend guidance being the same it seems like that imply a bit of a chance and where we are today in a low 50s maybe can help us understand what sort of drive some of the fluctuation in spend here and how we thinking about that going forward?

And I have a follow up. So we do expect lower spend in the back half of the year and certainly as the brand continues to grow that all bode well from our commercial margin expansion over the balance of the year.

Peter Hecht We've seen that trend average of the last two or three years as well. Eric Joseph Okay, reasonable to expect that going forward as we sort of breaking out and so forth?

Thomas Graney Yeah, as we've guided, we expect commercial margins to continue to expand and we will see you know not only quarterly prices, but also seasonal fluctuations in commercial margin, but we have said, we expected to be in the 70's by Eric Joseph Got it and maybe Mark, just on the you guys talked a bit about how you saw a dose response and I'm wholesale wondering given the tolerability profile spread of an eye and just how confident you are that you have a maximum expected dose it has mgs things with Phase b whether there's potential for higher dosing or are you kind of physically constrained at point?

Mark Currie Yeah, I think what we know is, we've got an active drug at the particular dotes level. We think that doses level bring meaningful benefit for potentially meaningful benefit for patient, so we're going to prosecute that it quickly and we can and as we've indicated, we will continue to innovate in the debate, we're the only innovator currently really addressing that patient population, we think is quite large, and we're looking at a lot of different ways in the future to continue to utilize the - what we've found around the bio laxatives hypothesis.

Eric Joseph Got it. Thanks for taking the questions guys. And our next question comes from the line of Irina Koffler from Mizuho Securities.

Irina Koffler Hi, thanks for taking my questions. That's the first question. And the second question is on the DR2 compound, can you just remind us again what type of pain model you will be targeting there and whether or not there is an FDA pathway or some sort of guidance to help you as you design the program? Peter Hecht Great, Mark you take the first couple? Mark Currie Yes, hi Irina. Looking at the formulation the weighted gastric retentive point formulation work, we think we can take go to two pills approach, because it's price the same pill, it change it very dipped slightly in size, the release profile we expect to be the same, but we'll be able to test that for sure.

But yes we think we can go directly into Phase III, because we're really not changing that formulate and other than a little bit on the size. We're very focused on not looking at IBS pain first thinking on non-constipated IBS pain and we think that previously there's been evident in the IBS guidance, that you can get a pain only label, so we feel pretty good about that, obviously we haven't we need to go in and do a 2b study and see the effect and then go and talk to the FDA, but that would be our approach which using the guidance on getting a pain component label for IBS.

Thomas Graney And then, this is Tom Graney, Irina just on the other sources of revenue, we got a couple of million in revenue from our two co-promotion agreements, the VIBERZI 1 and also the trailing consideration, we're getting from an arrangement that we ended.

And then the bulk of the difference is from ATI sales to other collaboration partners outside of the U. Irina Koffler Okay, thank you. Tim Chiang Hi, thanks. Just on DR1, have you guys already met with the FDA recently just wondering, and you have I mean you guys have a pretty good picture on how the Phase III study design will be set up the approach that date? Mark Currie Yeah Tim, this is Mark. We are having continuous interacting with the FDA at this stage and we advance towards Phase III, there's a number obviously of discussion we have to have the PRO discussion, end point discussion, the CMP discussions, pharmacokinetic discussion, so we're in the midst of both and we certainly well once we have settled on what the final path it will update what we - what the approach will be.

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The baby will befuture heir regardless of sex. Sinsky is on the leading edge of an innovation shaking up the practice of medicine: Think of the idealized patience, caring and individualized attention that actor Robert Young showed his patients on TV's "Marcus Welby, M.

That's what a medical home is like — and private practices, hospitals, health plans, Medicare and states are embracing and financing them. Today's parents tend to view baptism as more a pledge of faith than as a washing away of sin, says the report.

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Shadowrun fans turned out in droves to support the new project inpledging Democrats won the approval of 39 percent of the U. Officials said it was tooearly to say whether continued strong demand for the modeltrucks could result in even better pricing than GM initiallythought for the new models.

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Mehr said one protester threw his shoes at the car, a gesture ofdeep insult in the Islamic faith. The couple has lived together for more than six years. They are not allowed to adopt each other's children because the state of Michigan bans same sex marriage and they are considered two single adults living together.

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Unlike most nations, the U. Nearly 9 out 10 mortgages are guaranteed by the government. But he did not give many details of proposed reforms. He is not expected to play again until a European Tour event Nov.

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In Kenya and then Tanzania, I found the same to be true. Only in Zambia did the reality of these killer anopheles truly become a challenge to avoid. Zambia has some of the highest recorded malaria cases on earth, and I learned quickly why: But more than concrete detail, the pope is stressing a need for attitude change. If his vision of a church more embracing of its price takes root, that could mean greater influence in Vatican policy-making by church's bishops, who wholesale with the wide variety of issues allopurinol circumstances often particular to their churches.

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