Please talk to your doctor or pharmacist about these possibilities. All medicines can have side effects. Sometimes they are serious, most of the time they are not. You may need medical treatment if you get some of the side effects. Ask your doctor or pharmacist to answer any questions you may have. Tell your doctor if you notice any of the following and they worry you: The Physician's Study Group. Fagan TC, Haggert BE, Liss C "Efficacy and tolerability of extended-release felodipine and extended-release nifedipine in patients with mild-to-moderate essential hypertension.
Al-Niaimi F, Lyon C "Felodipine-induced eruptive telangiectasia following mastectomy and radiotherapy. What form s does this medication come in? How should I use this medication? The recommended adult dose of felodipine ranges from 2. The tablets should be swallowed whole and may be taken with or without food. Avoid taking this medication with a meal that is high in carbohydrates or fat e. Grapefruit juice increases the amount of felodipine in your body and should also be avoided.
In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic , renal , or cardiac function, and of concomitant disease or other drug therapy. In a suicide attempt, one patient took mg felodipine together with 15 tablets each of atenolol and spironolactone and 20 tablets of nitrazepam. The patient's blood pressure and heart rate were normal on admission to hospital; he subsequently recovered without significant sequelae.
Overdosage might be expected to cause excessive peripheral vasodilation with marked hypotension and possibly bradycardia. If severe hypotension occurs, symptomatic treatment should be instituted. The patient should be placed supine with the legs elevated. The administration of intravenous fluids may be useful to treat hypotension due to overdosage with calcium antagonists.
In case of accompanying bradycardia, atropine 0. Sympathomimetic drugs may also be given if the physician feels they are warranted. It has not been established whether felodipine can be removed from the circulation by hemodialysis.
To obtain up-to-date information about the treatment of overdose, consult your Regional Poison-Control Center. In managing overdose, consider the possibilities of multiple-drug overdoses, drug-drug interactions, and unusual drug kinetics in your patient.
It works by relaxing the muscles of your heart and blood vessels. Felodipine is used to treat hypertension high blood pressure. Felodipine may also be used for other purposes not listed in this medication guide. You should not use felodipine if you are allergic to it. Before taking felodipine, tell your doctor if you have liver disease or congestive heart failure.
Felodipine, at the doses employed in the 2-year rat study, has been shown to lower testicular testosterone and to produce a corresponding increase in serum luteinizing hormone in rats. The Leydig cell tumor development is possibly secondary to these hormonal effects which have not been observed in man. In this same rat study a dose-related increase in the incidence of focal squamous cell hyperplasia compared to control was observed in the esophageal groove of male and female rats in all dose groups.
No other drug-related esophageal or gastric pathology was observed in the rats or with chronic administration in mice and dogs. The latter species, like man, has no anatomical structure comparable to the esophageal groove. Felodipine was not carcinogenic when fed to mice at doses up to Felodipine did not display any mutagenic activity in vitro in the Ames microbial mutagenicity test or in the mouse lymphoma forward mutation assay.
A fertility study in which male and female rats were administered doses of 3. Based on patient weight of 50 kg Pregnancy: Teratogenic Effects — Studies in pregnant rabbits administered doses of 0. The frequency and severity of the changes appeared dose related and were noted even at the lowest dose. These changes have been shown to occur with other members of the dihydropyridine class and are possibly a result of compromised uterine blood flow.
Tell your doctor if you are lactose intolerant. Heart Failure Although acute hemodynamic studies in a small 5mg of patients with NYHA Class II or III heart failure treated with felodipine have not demonstrated negative inotropic effects, safety in patients with heart failure has not been established. What 5mg s does this medication come in? Before taking felodipine, tell your doctor if you have liver disease or congestive heart failure. This results in even felodipine plasma concentrations within the therapeutic range for 24 hours. These effects were attributed to the inhibitory effect of felodipine in high doses on buy generic crestor no prescription contractility. Biotransformation Felodipine is extensively metabolised in the liver by cytochrome P 3A4 CYP3A4 and all identified metabolites are inactive. Many medications can cause side effects. In cyclosporin-treated renal transplant recipients, felodipine reduces blood pressure and improves both the renal blood flow and the glomerular filtration rate. No other drug-related esophageal or gastric pathology plendil observed in the rats or with chronic administration in mice and dogs, plendil er 5mg. You should not use felodipine if you are allergic plendil it. In vitro studies show that the effects of felodipine on contractile processes are selective, plendil er 5mg, with greater effects on vascular smooth muscle than cardiac muscle. Patients with Impaired Liver Function Patients with impaired liver function may have elevated plasma concentrations of felodipine and may respond to lower doses of PLENDIL; therefore, a starting dose of 2.
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