You must not get dehydrated. Ask your doctor or health care professional how much fluid you need to drink a day. Check with him or her if you get an attack of severe diarrhea, nausea and vomiting, or if you sweat a lot. The loss of too much body fluid can make it dangerous for you to take this medicine. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child, particularly in the second or third trimester.

Talk to your health care professional or pharmacist for more information. You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this drug affects you.

Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol can make you more drowsy and dizzy. This medicine may affect your blood sugar level. If you have diabetes, check with your doctor or health care professional before changing the dose of your diabetic medicine. Avoid salt substitutes unless you are told otherwise by your doctor or health care professional.

Thiazides should be discontinued before carrying out tests for parathyroid function. Hydrochlorothiazide dose-dependently increases urinary potassium excretion which may result in hypokalaemia. This effect of hydrochlorothiazide seems to be less evident when combined with candesartan cilexetil.

The risk for hypokalaemia may be increased in patients with cirrhosis of the liver, in patients experiencing brisk diuresis, in patients with an inadequate oral intake of electrolytes and in patients receiving concomitant therapy with corticosteroids or adrenocorticotropic hormone ACTH. Concomitant use of Candesartan and Hydrochlorothiazide Tablets and ACE inhibitors, aliskiren, potassium-sparing diuretics, potassium supplements or salt substitutes or other medicinal products that may increase serum potassium levels e.

Monitoring of potassium should be undertaken as appropriate. Thiazides have been shown to increase the urinary excretion of magnesium, which may result in hypomagnesaemia. Metabolic and endocrine effects Treatment with a thiazide diuretic may impair glucose tolerance. Dose adjustment of antidiabetic medicinal products, including insulin, may be required.

Latent diabetes mellitus may become manifest during thiazide therapy. Increases in cholesterol and triglyceride levels have been associated with thiazide diuretic therapy. At the doses contained in Candesartan and Hydrochlorothiazide Tablets, only minimal effects were observed.

Thiazide diuretics increase serum uric acid concentration and may precipitate gout in susceptible patients. Cases of photosensitivity reactions have been reported during use of thiazide diuretics see section4. If a photosensitivity reaction occurs, it is recommended to stop treatment.

If re-administration of treatment is essential, it is recommended to protect areas exposed to the sun or to artificial UVA radiation. In patients whose vascular tone and renal function depend predominantly on the activity of the renin-angiotensin-aldosterone system e. As with any antihypertensive agent, excessive blood pressure decrease in patients with ischaemic heart disease or atherosclerotic cerebrovascular disease could result in a myocardial infarction or stroke. Hypersensitivity reactions to hydrochlorothiazide may occur in patients with or without a history of allergy or bronchial asthma, but are more likely in patients with such a history.

Exacerbation or activation of systemic lupus erythematosus has been reported with the use of thiazide diuretics. The antihypertensive effect of Candesartan and Hydrochlorothiazide Tablets may be enhanced by other antihypertensives. Unless continued AIIRA therapy is considered essential, patients planning pregnancy should be changed to alternative antihypertensive treatments which have an established safety profile for use in pregnancy.

When pregnancy is diagnosed, treatment with AIIRAs should be stopped immediately, and, if appropriate, alternative therapy should be started see sections 4. Do not use this medicine after the expiry date which is stated on the packaging after EXP. The expiry date refers to the last day of that month. This medicinal product does not require any special storage conditions. Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use.

These measures will help protect the environment. Each tablet contains 8 mg candesartan cilexetil and Each tablet contains 16 mg candesartan cilexetil and Each tablet contains 32 mg candesartan cilexetil and 25 mg hydrochlorothiazide.

Each tablet contains 32 mg candesartan cilexetil and The score line is only to facilitate breaking for ease of swallowing and not to divide into equal doses.

Atacand Plus (Candesartan/HCTZ)

You may 32mg/25mg tiredness, yellowing of your skin and the whites of your eyes and flu like symptoms. The loss of too much body fluid can 32mg/25mg it dangerous for you to take this medicine, candesartan 32mg/25mg. What may interact with this medicine? Rarely, it may cause liver problems. After single and repeated administration, the pharmacokinetics of candesartan are linear for oral doses up to 32 mg of candesartan cilexetil, candesartan 32mg/25mg. Its action is, therefore, independent of the pathways for angiotensin II synthesis. Candesartan Candesartan Cilexetil The volume of distribution of candesartan is 0. There is a potential for serious side effects to an unborn child, particularly in the second or third trimester, candesartan 32mg/25mg. Where should I keep my medicine? Treatment with a thiazide diuretic may impair glucose tolerance. Candesartan cilexetil was evaluated in the Ames test, the in vitro mouse lymphoma cell assay, the champix price nsw vivo rat hepatocyte unscheduled DNA synthesis assay and the in vivo mouse micronucleus test, in each case with negative results. Metabolism and Excretion Candesartan Cilexetil Total plasma clearance of candesartan is 0, candesartan 32mg/25mg. Seniors may be more sensitive to the effects of this medication and may experience more side effects, even at normal adult doses. As candesartan result, candesartan relaxes the blood vessels. Antidiabetic drugs oral agents and insulin - Dosage adjustment of the antidiabetic drug may be required. Thiazide diuretics increase serum uric acid concentration and may precipitate gout in susceptible patients.

Atacand Plus

This medicinal product does not require any special storage conditions. Second and third trimesters candesartan pregnancy see sections 4. Special warnings and precautions for use Dual blockade of the renin-angiotensin-aldosterone system RAAS There is evidence that the concomitant use of Candesartan, angiotensin II receptor blockers or aliskiren increases the risk of hypotension, hyperkalaemia and decreased renal function including acute renal failure. For oral dosage form tablets: In fact, many may feel normal, candesartan 32mg/25mg. Use of candesartan and hydrochlorothiazide with lithium is not recommended. Keep out of the reach of children, candesartan 32mg/25mg. Geriatric TOP Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of candesartan and hydrochlorothiazide combination in the elderly. Hydrochorothiazide was not genotoxic in vitro in the Ames test for 32mg/25mg mutations and the CHO test for chromosomal aberrations, or in vivo in assays using mouse germinal cell chromosomesChinese hamster bone marrow chromosomes, and the 32mg/25mg sex-linked recessive lethal trait gene. Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. In patients who are elderly, volume-depleted including those on diuretic therapyor with compromised renal function, co-administration of NSAIDs, including selective COX-2 inhibitors, with angiotensin II receptor antagonists, including candesartan, may result in deterioration of renal function, including candesartan acute renal failure. Thiazides have been shown to increase the urinary excretion of magnesium, candesartan 32mg/25mg, which may result in hypomagnesaemia. Systemic Lupus Erythematosus Thiazide diuretics have been reported to cause exacerbation or activation 32mg/25mg systemic lupus erythematosus.

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