Levaquin 750mg 5 days - Levofloxacin - FDA prescribing information, side effects and uses
Hemodialysis or Chronic Ambulatory Peritoneal Dialysis CAPD mg every 48 hours mg initial dose, then mg every 48 hours mg initial dose, then mg every 48 hours mg mg initial dose, then mg every 24 hours mg initial dose, then mg every 48 hours mg initial dose, then mg every 48 hours mg mg every 48 hours.
Antacids, Sucralfate, Metal Cations, Multivitamins Levofloxacin Injection should not 750mg co-administered with any solution containing multivalent cations, e. Administration Instructions Levofloxacin Injection Caution: Rapid or bolus days infusion of Levofloxacin has been associated with hypotension and must be avoided. Levofloxacin Injection should be infused intravenously levaquin over a period of not less than 60 or 90 minutes, depending on the dosage.
Levofloxacin Injection should be administered only by intravenous infusion. It is not for intramuscular, intrathecal, levaquin 750mg 5 days, intraperitoneal, or subcutaneous administration. Hydration for Patients Receiving Levofloxacin Injection Adequate hydration of patients receiving intravenous Levofloxacin should be maintained to prevent the formation of highly concentrated urine.
Crystalluria and cylindruria have been reported with quinolones [see Adverse Reactions 6. Preparation of Intravenous Product Parenteral drug products should be inspected visually 750mg particulate matter and discoloration prior to administration, whenever solution and container permit. Because only limited data are available on accutane gastric disorder compatibility of Levofloxacin Injection with other intravenous substances, additives or other medications should not be added to Levofloxacin Injection Premix in Single-Use Flexible Containers, or infused days through the same intravenous line.
If the same intravenous line is used for sequential infusion of several different drugs, the line should be flushed before and after infusion of Levofloxacin Injection with an infusion solution 750mg with Levofloxacin Injection levaquin with any other drug s administered via this common line, levaquin 750mg 5 days.
No days dilution of these levaquin is necessary.
Levofloxacin
Because the premix days containers are for single-use only, any unused portion should be discarded. Tear outer wrap at the notch and remove 750mg container.
Check the container for minute leaks by squeezing the inner bag firmly. If leaks are found, or if the seal levaquin not intact, levaquin 750mg 5 days, discard the solution, as the sterility may be compromised. Do not use if the solution is cloudy or a precipitate is present.
Do not use flexible containers in series connections. 750mg use could result in air embolism due to residual air being drawn from the primary container before administration of the fluid from levaquin secondary container is complete. Close flow control clamp of administration set. Remove cover from port at bottom of container.
Levofloxacin 750-mg for 5 days for the treatment of hospitalized Fine Risk Class III/IV community-acquired pneumonia patients.
Insert piercing pin of administration set into port with a twisting motion until the pin is firmly seated. See full directions on administration set carton.
Suspend container from hanger. Squeeze and release drip chamber to establish proper fluid level in chamber during infusion of Levofloxacin Injection Premix in Flexible Containers. Open flow control clamp to expel air from days. Regulate rate of administration with flow control clamp.
Warnings and Precautions Disabling and Potentially Irreversible Serious Adverse Reactions Including Tendinitis and Tendon Rupture, Peripheral Neuropathy, and Central Nervous System Effects Fluoroquinolones, including Levofloxacin, 750mg been associated with disabling and potentially irreversible serious adverse reactions from different body systems that can occur together in the same patient, levaquin 750mg 5 days.
Commonly seen adverse reactions include tendinitis, tendon rupture, arthralgia, myalgia, peripheral neuropathy, and central nervous system effects hallucinations, anxiety, levaquin 750mg 5 days, depression, insomnia, severe headaches, levaquin confusion. These reactions can occur within hours to weeks after starting Levofloxacin. Patients of any age or without pre-existing risk factors have experienced these adverse reactions [see Warnings and Precautions 5. Discontinue Levofloxacin immediately at the first signs or symptoms of any serious adverse reaction.
Efficacy of 750-mg, 5-day levofloxacin in the treatment of community-acquired pneumonia caused by atypical pathogens.
In addition, avoid the use of fluoroquinolones, including Levofloxacin, in levaquin who have experienced any of these serious adverse reactions associated with fluoroquinolones.
Tendinitis and Days Rupture Fluoroquinolones, including Levofloxacin, have been associated with an increased risk of tendinitis and levaquin rupture in all ages [see Warnings and Precautions 5. This adverse reaction most frequently involves the Achilles tendon and has also been reported with the rotator cuff the shoulderthe hand, the biceps, the thumb, and other tendon sites.
Tendinitis or tendon rupture can occur within hours or days of starting Levofloxacin or as long as several months is 500mg of folic acid enough completion of 750mg therapy. Tendinitis and tendon rupture can occur bilaterally, levaquin 750mg 5 days.
The risk of days fluoroquinolone-associated tendinitis and tendon rupture is increased in patients over 60 years of age, in those taking corticosteroid drugs, and 750mg patients with kidney, heart or lung transplants. Other factors that may independently increase the risk of tendon rupture include strenuous physical activity, renal failure, and previous tendon disorders such as rheumatoid arthritis.
Tendinitis and tendon rupture have been reported in patients taking fluoroquinolones who do not have the above risk factors. Discontinue Levofloxacin immediately if the patient experiences pain, swelling, inflammation or rupture of a tendon.
Patients should be advised to rest at the first sign of tendinitis or tendon rupture, and to contact their healthcare provider regarding changing to a non-quinolone antimicrobial drug. Avoid Levofloxacin in patients who have a history of tendon levaquin or tendon rupture [see Adverse Reactions 6. Peripheral Neuropathy Fluoroquinolones, including Levofloxacin, have been 750mg with an increased risk of peripheral neuropathy, levaquin 750mg 5 days. Symptoms may occur levaquin after initiation of Levofloxacin and may be irreversible in some patients [see Warnings 750mg Precautions 5.
Avoid fluoroquinolones, including Levofloxacin, in patients who have previously experienced peripheral neuropathy [see Adverse Reactions 6levaquin 750mg 5 days, Patient Counseling Information Fluoroquinolones may also 750mg central nervous system stimulation which may lead to tremors, restlessness, levaquin 750mg 5 days, anxiety, lightheadedness, confusion, hallucinations, paranoia, depression, days, and insomnia.
Suicidal thoughts, levaquin 750mg 5 days, and attempted or completed suicide may also occur, levaquin 750mg 5 days, 750mg in patients with a medical history of depression, levaquin 750mg 5 days, or an underlying risk factor for depression. These reactions may occur following the first dose.
If these reactions occur in patients receiving Levofloxacin, discontinue 750mg and institute appropriate measures. As with other fluoroquinolones, Levofloxacin should be used with caution in patients with a known or suspected central nervous system CNS disorder that may predispose them to seizures or lower the seizure threshold e. Exacerbation of Myasthenia Gravis Fluoroquinolones, including Levaquin, have neuromuscular blocking activity and may exacerbate muscle weakness in patients with myasthenia gravis.
Postmarketing serious adverse reactions including deaths and requirement for ventilatory support, have been days with fluoroquinolone use in patients with myasthenia gravis. Avoid Levofloxacin in patients with a known history of levaquin gravis [see Adverse Reactions 6.
Other Serious levaquin Sometimes Fatal Adverse Reactions Other serious and sometimes fatal adverse reactions, some due to hypersensitivity, and some due to uncertain etiology, have been reported rarely in patients receiving therapy with fluoroquinolones, including Levofloxacin.
These events may be severe and generally occur following the administration of multiple doses. Clinical manifestations may include one or more of the following: Discontinue Levofloxacin immediately at the first appearance of skin rash, jaundice, or any other sign of hypersensitivity and institute supportive measures [see Adverse Reactions 6 ; Patient Counseling Information These reactions often occur 750mg the first dose.
Levofloxacin should be discontinued immediately at the first appearance of a skin rash or any other sign of hypersensitivity. Serious acute hypersensitivity reactions may require treatment with epinephrine and other resuscitative measures, including oxygen, intravenous fluids, antihistamines, corticosteroids, pressor amines, and airway management, as clinically indicated [see Adverse Reactions 6 ; Patient Counseling Information Hepatotoxicity Post-marketing reports of severe hepatotoxicity including acute hepatitis and fatal events have been received for patients treated with levofoxacin.
No evidence of serious drug-associated hepatotoxicity was detected in clinical trials of over 7, patients. Severe hepatotoxicity generally occurred within 14 days of initiation of therapy and most cases occurred within 6 days.
Most cases of severe hepatotoxicity were not associated with hypersensitivity [see Warnings and Precautions 5. The majority of days hepatotoxicity reports occurred in patients 65 years of age or older and levaquin were not associated with hypersensitivity. Levofloxacin should be discontinued immediately if the patient develops signs and symptoms of hepatitis 750mg Adverse Reactions 6 ; Patient Counseling Information Clostridium difficile-Associated Diarrhea Clostridium difficile-associated diarrhea CDAD has been days with use of days all antibacterial agents, including Levofloxacin, and levaquin range in severity from mild diarrhea to fatal colitis.
Treatment with antibacterial agents alters the normal flora of the colon leading to overgrowth of C. Hypertoxin producing strains of C. CDAD must be considered in all patients who present with diarrhea following antibiotic use. Careful medical history is necessary since CDAD has been reported to occur over two months after the administration of antibacterial agents.
Appropriate fluid and electrolyte management, protein supplementation, antibiotic treatment of C. Prolongation of the QT Interval Some fluoroquinolones, including Levofloxacin, have been days with prolongation of the QT interval on the electrocardiogram and infrequent cases of arrhythmia.
Rare cases of torsade de pointes have been spontaneously reported during postmarketing surveillance in patients receiving levaquin, including Levofloxacin. Levofloxacin should be avoided in patients with known prolongation of the QT interval, patients with uncorrected hypokalemia, and patients receiving Class IA quinidine, procainamide 750mg, or Class III amiodarone, levaquin 750mg 5 days, sotalol antiarrhythmic agents.
Elderly patients may be days susceptible 750mg drug-associated effects on the QT interval [see Adverse Reactions 6. Musculoskeletal Disorders in Pediatric Patients and Arthropathic Effects in Animals Levofloxacin is days in levaquin patients 6 months levaquin age and older only for the prevention of inhalational anthrax post-exposure and for plague [see Indications and Usage 1. An days incidence of musculoskeletal disorders arthralgia, arthritis, tendinopathy, and gait abnormality compared 750mg controls has been observed in pediatric patients receiving Levofloxacin [see Use in Specific Populations voltaren gel order. In immature rats and dogs, the oral and intravenous administration of Levofloxacin resulted in increased osteochondrosis.
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Histopathological examination of the weight-bearing joints of immature dogs dosed with Levofloxacin revealed persistent lesions of the cartilage, levaquin 750mg 5 days. Blood Glucose Disturbances As with other fluoroquinolones, disturbances of blood glucose, including symptomatic hyper- and hypoglycemia, have been reported with Levofloxacin, usually in diabetic patients receiving concomitant treatment with an oral hypoglycemic agent e.
In these patients, 750mg monitoring of blood glucose is recommended. If a hypoglycemic reaction occurs in a patient being avelox price list with Levofloxacin, Levofloxacin should be discontinued and appropriate therapy should be initiated immediately [see Adverse Reactions 6. Therefore, excessive exposure to these sources of days should be avoided.
Development of Drug Resistant Bacteria Prescribing Levofloxacin in the absence levaquin a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria [see Patient Counseling Information Adverse Reactions Serious and Otherwise Important Adverse Reactions The following serious and otherwise important adverse drug reactions are discussed in greater detail in other sections of labeling:
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